CarModelProblems.com

2006 Mercedes-Benz E350 Problems & Recalls

Built from official NHTSA complaint and recall data · data through 07/14/2026

High complaint levelIts most-reported problem — Fuel/propulsion System — runs 8.5× the fleet median for that category across the 1401 model-years tracked on this site.
398Complaints
4Recalls
14Crashes
9Fires
18Injured
1Deaths

Source: U.S. NHTSA complaint & recall data. Complaints are unverified reports from vehicle owners — a complaint is not a confirmed defect.

Is this problem acknowledged?

The most-reported problem — Fuel/propulsion System (36.2% of complaints) — was examined in a now-closed NHTSA investigation that did not result in a recall.

Fuel/propulsion System complaints here are 8.5× the median for that category across the 1401 model-years tracked on this site.

None of the 6 most-reported categories on this page have a recall or open investigation on file — they rest on unverified owner reports alone.

Complaint categoryReportsOfficial statusReference
Fuel/propulsion System144 · 36.2%Investigation closedEA13003
Fuel System, Gasoline75 · 18.8%Investigation closedEA13003
Engine50 · 12.6%No official action
Service Brakes46 · 11.6%No official action
Power Train29 · 7.3%No official action
Electrical System14 · 3.5%Investigation closedPE10017

Recalled = an NHTSA safety recall covers this category, so a free repair exists. Under investigation = NHTSA has an open probe but no recall yet. Investigation closed = NHTSA examined it and closed the probe — this is not a defect finding; where a closed probe led to a recall we name the campaign. Not available = recall or investigation data could not be confirmed for this vehicle — it is not a “no”. Categories are matched by NHTSA's top-level component. Check your VIN at nhtsa.gov/recalls.

Complaints by component

ENGINE50 · 12.6%
SERVICE BRAKES46 · 11.6%
POWER TRAIN29 · 7.3%
ELECTRICAL SYSTEM14 · 3.5%
ENGINE AND ENGINE COOLING14 · 3.5%
AIR BAGS11 · 2.8%
Unspecified / other10 · 2.5%
POWER TRAIN:AUTOMATIC TRANSMISSION8 · 2%

Percentages are the share of the 398 complaints citing each component; one complaint can cite several components. “Unspecified / other” is NHTSA’s own catch-all category — we show it rather than hide it.

Recalls — 4 campaigns

Visibility:sun/moon Roof Assembly

NHTSA campaign 21V196000 · 2021 · reported 03/19/2021

A detached glass panel can separate from the vehicle and become a road hazard, increasing the risk of a crash. Recall repairs are free at authorized dealers.

PARK-IT: NO  · PARK-OUTSIDE: NO  ·  OVER-THE-AIR FIX: NO

Visibility:sun/moon Roof Assembly

NHTSA campaign 19V918000 · 2019 · reported 12/20/2019

A detached glass panel can separate from the vehicle and become a road hazard, increasing the risk of a crash. Recall repairs are free at authorized dealers.

PARK-IT: NO  · PARK-OUTSIDE: NO  ·  OVER-THE-AIR FIX: NO

Visibility:sun/moon Roof Assembly

NHTSA campaign 22V954000 · 2022 · reported 12/23/2022

A detached sunroof panel may become a road hazard, increasing the risk of a crash. Recall repairs are free at authorized dealers.

PARK-IT: NO  · PARK-OUTSIDE: NO  ·  OVER-THE-AIR FIX: NO

Visibility:sun/moon Roof Assembly

NHTSA campaign 24V874000 · 2024 · reported 11/19/2024

A detached sunroof panel can become a road hazard, increasing the risk of a crash. Recall repairs are free at authorized dealers.

PARK-IT: NO  · PARK-OUTSIDE: NO  ·  OVER-THE-AIR FIX: NO

Park it Park outside Specimen badges — shown on a recall card only when NHTSA sets the flag. None of the campaigns above carries either flag. Always check your own vehicle by VIN at nhtsa.gov/recalls.

What owners report

“THE CONTACT OWNS A 2006 MERCEDES E-350. THE CONTACT STATED THAT AFTER THE VEHICLE WAS PARKED OVERNIGHT, THE CONTACT LATER NOTICED GASOLINE FUMES INSIDE THE…”NHTSA complaint 10511251 — filed 05/09/2013 · FUEL/PROPULSION SYSTEM
“I AM EXPERIENCING HIGHLY INTOXICATING FUMES COMING FROM THE VEHICLE GAS TANK. I CAN NO LONGER PARK VEHICLE INSIDE MY GARAGE FOR FEAR OF AN…”NHTSA complaint 10509707 — filed 04/26/2013 · FUEL/PROPULSION SYSTEM
“FOLLOWING FILL-UP AND ONLY WHEN TANK IS FUEL, STRONG ODOR OF FUEL IN GARAGE. TALKED TO MECHANIC THAT INSPECTED VEHICLE. FOUND RESEARCH ONLINE DESCRIBING SIMILAR…”NHTSA complaint 10509114 — filed 04/22/2013 · FUEL/PROPULSION SYSTEM

Excerpts are shortened and scrubbed of personal details; they are individual, unverified reports.

Complaint trend by year filed

3320114371201382562015233920171718201924142021932023552025

Frequently asked questions

What are the most common problems with the 2006 Mercedes-Benz E350?

Fuel/propulsion system issues are the most-reported category, cited in 144 of 398 NHTSA complaints (36.2%), followed by fuel system, gasoline (75), engine (50), service brakes (46). Complaints are unverified owner reports.

How many complaints does the 2006 Mercedes-Benz E350 have?

398 complaints were on file with NHTSA as of 07/14/2026. Of those, 14 involved a crash, 9 involved a fire, and 18 reported injuries. 1 deaths were reported.

Does the 2006 Mercedes-Benz E350 have any recalls?

Yes — 4 NHTSA safety recall campaigns, including campaign 21V196000. Recall repairs are free at authorized dealers. Check your specific vehicle by VIN at nhtsa.gov/recalls.

Has NHTSA acted on the 2006 Mercedes-Benz E350's reported problems?

0 of the 6 most-reported complaint categories on this page are backed by an NHTSA safety recall or open investigation; the rest are unverified owner reports. A recall means a free repair is available at authorized dealers.

Is a complaint proof of a defect?

No. Complaints are reports submitted by consumers to NHTSA. NHTSA does not verify individual complaints, and a complaint is not proof that a defect exists.

About this data — Complaint figures on this page are consumer reports submitted to the National Highway Traffic Safety Administration (NHTSA), a U.S. government agency. NHTSA does not verify individual complaints; a complaint is not proof that a defect exists, and counts reflect what owners chose to report, not confirmed failure rates. Recall information comes from official NHTSA safety recall campaigns; recall repairs are free at authorized dealers. Always check your specific vehicle by VIN at nhtsa.gov/recalls. CarModelProblems.com is an independent site and is not affiliated with NHTSA or any vehicle manufacturer. Data through 07/14/2026.