Built from official NHTSA complaint and recall data · data through 07/14/2026
High complaint levelIts most-reported problem — Fuel/propulsion System — runs 8.5× the fleet median for that category across the 1401 model-years tracked on this site.
398Complaints
4Recalls
14Crashes
9Fires
18Injured
1Deaths
Source: U.S. NHTSA complaint & recall data. Complaints are unverified reports from vehicle owners — a complaint is not a confirmed defect.
Is this problem acknowledged?
The most-reported problem — Fuel/propulsion System (36.2% of complaints) — was examined in a now-closed NHTSA investigation that did not result in a recall.
Fuel/propulsion System complaints here are 8.5× the median for that category across the 1401 model-years tracked on this site.
None of the 6 most-reported categories on this page have a recall or open investigation on file — they rest on unverified owner reports alone.
Complaint category
Reports
Official status
Reference
Fuel/propulsion System
144 · 36.2%
Investigation closed
EA13003
Fuel System, Gasoline
75 · 18.8%
Investigation closed
EA13003
Engine
50 · 12.6%
No official action
—
Service Brakes
46 · 11.6%
No official action
—
Power Train
29 · 7.3%
No official action
—
Electrical System
14 · 3.5%
Investigation closed
PE10017
Recalled = an NHTSA safety recall covers this category, so a free repair exists. Under investigation = NHTSA has an open probe but no recall yet. Investigation closed = NHTSA examined it and closed the probe — this is not a defect finding; where a closed probe led to a recall we name the campaign. Not available = recall or investigation data could not be confirmed for this vehicle — it is not a “no”. Categories are matched by NHTSA's top-level component. Check your VIN at nhtsa.gov/recalls.
Percentages are the share of the 398 complaints citing each component; one complaint can cite several components. “Unspecified / other” is NHTSA’s own catch-all category — we show it rather than hide it.
A detached glass panel can separate from the vehicle and become a road hazard, increasing the risk of a crash. Recall repairs are free at authorized dealers.
PARK-IT: NO · PARK-OUTSIDE: NO · OVER-THE-AIR FIX: NO
A detached glass panel can separate from the vehicle and become a road hazard, increasing the risk of a crash. Recall repairs are free at authorized dealers.
PARK-IT: NO · PARK-OUTSIDE: NO · OVER-THE-AIR FIX: NO
A detached sunroof panel can become a road hazard, increasing the risk of a crash. Recall repairs are free at authorized dealers.
PARK-IT: NO · PARK-OUTSIDE: NO · OVER-THE-AIR FIX: NO
Park itPark outside Specimen badges — shown on a recall card only when NHTSA sets the flag. None of the campaigns above carries either flag. Always check your own vehicle by VIN at nhtsa.gov/recalls.
What owners report
“THE CONTACT OWNS A 2006 MERCEDES E-350. THE CONTACT STATED THAT AFTER THE VEHICLE WAS PARKED OVERNIGHT, THE CONTACT LATER NOTICED GASOLINE FUMES INSIDE THE…”NHTSA complaint 10511251 — filed 05/09/2013 · FUEL/PROPULSION SYSTEM
“I AM EXPERIENCING HIGHLY INTOXICATING FUMES COMING FROM THE VEHICLE GAS TANK. I CAN NO LONGER PARK VEHICLE INSIDE MY GARAGE FOR FEAR OF AN…”NHTSA complaint 10509707 — filed 04/26/2013 · FUEL/PROPULSION SYSTEM
“FOLLOWING FILL-UP AND ONLY WHEN TANK IS FUEL, STRONG ODOR OF FUEL IN GARAGE. TALKED TO MECHANIC THAT INSPECTED VEHICLE. FOUND RESEARCH ONLINE DESCRIBING SIMILAR…”NHTSA complaint 10509114 — filed 04/22/2013 · FUEL/PROPULSION SYSTEM
Excerpts are shortened and scrubbed of personal details; they are individual, unverified reports.
Complaint trend by year filed
Frequently asked questions
What are the most common problems with the 2006 Mercedes-Benz E350?
Fuel/propulsion system issues are the most-reported category, cited in 144 of 398 NHTSA complaints (36.2%), followed by fuel system, gasoline (75), engine (50), service brakes (46). Complaints are unverified owner reports.
How many complaints does the 2006 Mercedes-Benz E350 have?
398 complaints were on file with NHTSA as of 07/14/2026. Of those, 14 involved a crash, 9 involved a fire, and 18 reported injuries. 1 deaths were reported.
Does the 2006 Mercedes-Benz E350 have any recalls?
Yes — 4 NHTSA safety recall campaigns, including campaign 21V196000. Recall repairs are free at authorized dealers. Check your specific vehicle by VIN at nhtsa.gov/recalls.
Has NHTSA acted on the 2006 Mercedes-Benz E350's reported problems?
0 of the 6 most-reported complaint categories on this page are backed by an NHTSA safety recall or open investigation; the rest are unverified owner reports. A recall means a free repair is available at authorized dealers.
Is a complaint proof of a defect?
No. Complaints are reports submitted by consumers to NHTSA. NHTSA does not verify individual complaints, and a complaint is not proof that a defect exists.
About this data — Complaint figures on this page are consumer reports submitted to the National Highway Traffic Safety Administration (NHTSA), a U.S. government agency. NHTSA does not verify individual complaints; a complaint is not proof that a defect exists, and counts reflect what owners chose to report, not confirmed failure rates. Recall information comes from official NHTSA safety recall campaigns; recall repairs are free at authorized dealers. Always check your specific vehicle by VIN at nhtsa.gov/recalls. CarModelProblems.com is an independent site and is not affiliated with NHTSA or any vehicle manufacturer. Data through 07/14/2026.
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