2006 Mercedes-Benz E350 Engine Problems

NHTSA component category: ENGINE · data through 07/14/2026

50Engine complaints

12.6%Of all 398 complaints

#3Most-reported category

Source: U.S. NHTSA complaint data. Complaints are unverified reports from vehicle owners — a complaint is not a confirmed defect.

How engine ranks on this vehicle

FUEL/PROPULSION SYSTEM144 · 36.2%

FUEL SYSTEM, GASOLINE75 · 18.8%

ENGINE50 · 12.6%

SERVICE BRAKES46 · 11.6%

POWER TRAIN29 · 7.3%

Share of the 398 complaints citing each category; one complaint can cite several. Full breakdown on the 2006 Mercedes-Benz E350 overview page.

What owners report

“THE CONTACT OWNS A 2006 MERCEDES BENZ E-350. THE CONTACT STATED THAT WHILE DRIVING APPROXIMATELY 20 MPH, THE VEHICLE JERKED AND THE CHECK ENGINE WARNING…”NHTSA complaint 10502808 — filed 03/14/2013

“I HAVE APPR. 64,0000 MILES ON MY MERCEDES E350 AND THE CHECK ENGINE LIGHT CAME ON. SENT IT TO THE MERCEDES DEALERSHIP AND SAID THAT…”NHTSA complaint 10483858 — filed 11/09/2012

“I HAD SO MANY PROBLEM WITH MY MERCEDES E350, BUT WHEN THE ENGINE LIGHT WAS ON I COULDN'T BELIEVE WAS THE BALANCE SHAFT. IT WAS…”NHTSA complaint 10480608 — filed 10/15/2012

Excerpts are shortened and scrubbed of personal details; they are individual, unverified reports.

Engine complaints by year filed

Frequently asked questions

Does the 2006 Mercedes-Benz E350 have engine problems?

Engine is the #3 most-reported problem area on the 2006 Mercedes-Benz E350: 50 of 398 complaints on file (12.6%). Complaints are unverified owner reports, not confirmed defects.

How many complaints does the 2006 Mercedes-Benz E350 have in total?

398 complaints were on file with NHTSA as of 07/14/2026. Across all categories, 14 involved a crash, 9 involved a fire, 18 reported injuries, and 1 reported deaths.

What does NHTSA's engine category include?

NHTSA assigns each complaint to standard component categories; this page reports the ENGINE category exactly as NHTSA defines and records it.

About this data — Complaint figures on this page are consumer reports submitted to the National Highway Traffic Safety Administration (NHTSA), a U.S. government agency. NHTSA does not verify individual complaints; a complaint is not proof that a defect exists, and counts reflect what owners chose to report, not confirmed failure rates. Recall information comes from official NHTSA safety recall campaigns; recall repairs are free at authorized dealers. Always check your specific vehicle by VIN at nhtsa.gov/recalls. CarModelProblems.com is an independent site and is not affiliated with NHTSA or any vehicle manufacturer. Data through 07/14/2026.